Formula details
Product Details
Overview
Sodium Chlorodifluoroacetate Technical Specifications
Finding a reliable supply of high-purity organofluorine reagents with low moisture content can be a challenge for large-scale operations. We manufacture and supply high-grade Sodium chlorodifluoroacetate engineered for rigorous industrial decarboxylation and fluorination processes.
CAS 1895-39-2 Quality Parameters
| Specification Parameter | Technical Standard | Test Method |
|---|---|---|
| Product Name | Sodium chlorodifluoroacetate | Standard |
| CAS Number | 1895-39-2 | Standard |
| Synonyms | Sodium 2-chloro-2,2-difluoroacetate; Chlorodifluoroacetic acid sodium salt | Chemical Nomenclature |
| Chemical Formula | ClCF2CO2Na | Structural Standard |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay Purity | >= 99.0% | HPLC / Titration |
| Melting Point | 195 °C to 201 °C (decomposes) | Thermal Analysis |
| Moisture Content | <= 0.5% | Karl Fischer (KF) |
| Insoluble Matter | <= 0.1% | Water Dissolution |
Recommended Storage & Stability Conditions
This high purity fluorinated building block requires precise handling to prevent degradation:
- Atmospheric Control: Store under an inert gas cover (nitrogen or argon) in a cool, dry, and well-ventilated space.
- Temperature Management: Maintain temperatures below 15 °C for long-term storage stability.
- Moisture Prevention: Keep packaging tightly sealed to guard this hydro-sensitive fluorinated organofluorine salt against atmospheric moisture absorption.
Synthetic Utility & Industrial Applications of Sodium Chlorodifluoroacetate
Difluorocarbene Precursor Reagent
We deploy sodium chlorodifluoroacetate as a reliable, cost-effective source for generating active difluorocarbene (:CF2) in industrial organic synthesis.
- Decarboxylative Cleavage: Thermally undergoes smooth decarboxylation in polar aprotic solvents (such as diglyme or DMF) at operational temperatures of 90–120 °C.
- gem-Difluorocyclopropanation: Reacts efficiently with unsaturated substrates—including alkenes and alkynes—to yield fluorinated carbocyclic ring systems without requiring high-pressure equipment.
Selective Decarboxylative Difluoromethylation
As an atom-efficient alternative to hazardous chlorodifluoromethane gas (CHClF2) or cost-prohibitive reagents like TMSCF3, our high-purity material streamlines difluoromethyl group introduction.
- Substrate Compatibility: Enables direct conversion of aromatic and heteroaromatic thiols, nitrogen heterocycles, and selenium species into difluoromethylated derivatives (-CHF2).
- Pharmaceutical Optimization: Crucial for fine-tuning lipophilicity, membrane permeability, and metabolic stability during drug candidate development.
Direct 1,1-Difluoro Olefin Synthesis
Through triphenylphosphine (PPh3)-mediated pathways, sodium chlorodifluoroacetate provides a direct route for carbonyl functionalization.
| Target Class | Reagents | Reaction Route | Resulting Structure |
|---|---|---|---|
| Aldehydes & Ketones | PPh3 / Aprotic Solvent | Wittig-like decarboxylative olefination | 1,1-Difluoroalkenes in high yields |
High Purity Fluorinated Building Block for Lifesciences
We supply this fluorinated organofluorine salt (CAS 1895-39-2) as an essential core intermediate across critical sectors:
- Active Pharmaceutical Ingredients (APIs): Facilitates key fluoro-functionalization steps in small-molecule drug manufacturing.
- Crop Protection Agents: Serves as a core agrochemical fluorinated reagent for synthetic herbicides and pesticides.
- Advanced Specialty Chemicals: Acts as a scalable organofluorine precursor for complex fluorinated material production.
Greenlano Quality Assurance & Regulatory Compliance
We maintain rigorous analytical and manufacturing standards to ensure every shipment of sodium chlorodifluoroacetate meets exact technical specifications. As an SDS certified chemical supplier, Greenlano delivers verified purity, batch traceability, and full regulatory transparency for industrial buyers worldwide.
Strict Batch-to-Batch Quality Control
Every production lot undergoes rigorous analytical testing prior to dispatch to ensure strict adherence to high quality standards.
- Analytical Verification: Every batch is tested using HPLC, GC, and Karl Fischer titration to confirm purity and moisture parameters.
- Complete Traceability: End-to-end tracking from initial raw material selection down to final sealed packaging.
Complete Documentation Package
We streamline your regulatory audit trails by delivering standard documentation packages with every shipment.
| Document / Standard | Compliance Details | Key Parameters Covered |
|---|---|---|
| Certificate of Analysis (COA) | Provided with every order | Assay (>= 99.0%), moisture (<= 0.5%), insoluble matter |
| Safety & Technical Data | GHS-compliant SDS / MSDS & TDS | Safe handling, storage guidelines, hazard classification |
| Facility Certification | ISO 9001 Certified | Standardized manufacturing and quality control systems |
| Regulatory Support | REACH Compliance Support | Guidance for smooth international customs clearings |
Pre-Shipment Inspection
We offer flexible verification options to give you complete peace of mind before international dispatch.
- Third-Party Verification: Optional independent sampling and testing conducted by SGS or Bureau Veritas upon request.
- Custom Testing Protocols: Third-party verification tailored to your specific process purity requirements.
Packaging Options & Logistics for Sodium Chlorodifluoroacetate
We supply sodium chlorodifluoroacetate in high-integrity, moisture-barrier packaging tailored for R&D testing and full-scale commercial manufacturing.
Standard and Custom Packaging Options
| Scale | Volume | Packaging Type |
|---|---|---|
| Lab & R&D | 100 g, 500 g, 1 kg, 5 kg | Sealed amber glass or PE bottles |
| Commercial Bulk | 25 kg drum formats | Fiber drums with double-layer inner PE moisture-barrier bags |
We also offer customized bulk container setups to fit seamlessly into your local plant operations.
UN-Compliant Export & Hazardous Transport
Our global logistics team manages the complete supply chain to ensure safe and fully certified international transport of sodium chlorodifluoroacetate:
- UN Hazardous Standard Compliance: Certified export packaging that adheres strictly to UN regulations for shipping organofluorine chemical salts.
- Moisture & Environment Control: Double-sealed protective liners prevent ambient humidity absorption during long-distance shipping.
- Express Sample Air Cargo: Fast air freight dispatch for rapid sample inspection and preliminary testing.
- Bulk Global Shipping: Consolidated sea freight and ISO container shipping solutions for multi-ton industrial orders.
Safe Handling & GHS Hazard Classification
We prioritize workplace safety and strict regulatory compliance across every stage of handling Sodium chlorodifluoroacetate (CAS 1895-39-2). As an SDS certified chemical supplier, we provide full hazard transparency and direct safety protocols to protect your technical team during industrial processing.
GHS Safety Summary
| Parameter | Standard Classification |
|---|---|
| GHS Signal Word | Warning |
| Primary Hazards | Skin, eye, and respiratory tract irritation |
Hazard Statements
- H315: Causes skin irritation.
- H319: Causes serious eye irritation.
- H335: May cause respiratory irritation.
Precautionary Statements & Handling Guidelines
Follow standard protective protocols when transferring or processing this fluorinated chemical intermediate:
- P261: Avoid breathing dust, fumes, gas, mist, vapors, or spray. Always use under adequate localized exhaust ventilation.
- P280: Wear appropriate protective gloves, protective clothing, eye protection, and face protection.
- P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do, then continue rinsing.
Note: Access our complete GHS-compliant Safety Data Sheet (SDS) for detailed spill management and personal protection equipment (PPE) recommendations.
Frequently Asked Questions for Bulk Buyers
We address core technical and procurement queries regarding Sodium chlorodifluoroacetate (CAS 1895-39-2) to ensure a seamless integration into your commercial manufacturing workflows.
| Inquiry Focus | Key Details & Operational Parameters |
|---|---|
| Vs. Brominated Analog | Superior cost efficiency; decarboxylates efficiently at 90–120 °C |
| Shipping Lead Times | Catalog stock: Within 48 hours | Bulk orders (500 kg+): 10–15 business days |
| Custom Synthesis | Tailored purity grades up to ≥ 99.5%, custom drying, and specialized particle sizing |
Sodium Chlorodifluoroacetate vs. Sodium Bromodifluoroacetate
Q: What is the primary operational difference between Sodium chlorodifluoroacetate and its brominated analog?
- Cost Efficiency: Sodium chlorodifluoroacetate is significantly more cost-effective for large-scale industrial production, making it the preferred difluorocarbene precursor reagent for bulk manufacturing.
- Thermal Activation: It undergoes decarboxylative cleavage at slightly higher reaction temperatures (90–120 °C) in polar aprotic solvents compared to the brominated variant.
Bulk Lead Times and Global Delivery
Q: What is the typical lead time for commercial bulk orders at Greenlano?
- Standard Catalog Orders: R&D and pilot quantities ship within 48 hours.
- Commercial Bulk Orders: Deliveries ranging from 500 kg to multi-ton volumes are fulfilled within 10–15 business days, depending on your destination logistics and custom packaging requirements.
Custom Purity and Processing Options
Q: Can Greenlano supply custom purity grades or specialized particle sizes?
- High-Purity Options: Our custom synthesis team produces high-purity grades tailored up to ≥ 99.5% upon request.
- Custom Processing: We support specialized drying, micronization, and controlled particle-size distribution specifications to fit your specific reactor parameters.