Formula details
Product Details
Overview
Pyrazole Specification
We manufacture and supply high-purity 1H-pyrazole for global pharmaceutical, agrochemical, and fine chemical synthesis. Below is the quick reference specification for bulk procurement and technical evaluation.
Pyrazole Chemical Technical Data
| Property / Parameter | Specification / Details |
|---|---|
| Product Name | Pyrazole (1H-pyrazole) |
| CAS No. | 288-13-1 |
| Synonyms | 1,2-Diazole, Pyrazol, 1H-Pyrazole |
| Molecular Formula | C3H4N2 |
| Molecular Weight | 68.08 g/mol |
| Purity | ≥ 99.0% (GC/HPLC) |
| Appearance | White to off-white crystalline powder or flakes |
| Melting Point | 67°C – 70°C |
| Boiling Point | 186°C – 188°C |
| Solubility | Soluble in water, alcohol, ether, and chloroform |
| Storage Conditions | Store in a cool, dry, well-ventilated warehouse; keep container tightly sealed away from strong oxidizers |
| Packaging Options | 25 kg fiber drums, moisture-proof aluminum foil bags, or customized bulk packaging |
| Shelf Life | 24 months when stored in sealed original packaging under recommended conditions |
| Hazard Classification | GHS Hazard Class 4 (Harmful if swallowed); Causes serious eye irritation (GHS Category 2A) |
What Is Pyrazole?
Pyrazole is a foundational five-membered heterocyclic compound containing two adjacent nitrogen atoms in an aromatic ring. As a versatile pyrazole chemical, it serves as a core pyrazole intermediate widely utilized in modern chemical manufacturing and custom organic synthesis.
Core Structural Characteristics
| Parameter | Technical Details |
|---|---|
| IUPAC Name | 1H-Pyrazole |
| Ring System | 5-membered aromatic ring (3 carbons, 2 adjacent nitrogens) |
| Electronic Nature | Planar 6-π-electron aromatic system |
| Chemical Behavior | Amphoteric ring with customizable substitution sites |
Essential Intermediate in Fine Chemicals
We supply 1H-pyrazole as a critical building block because its ring structure imparts specific biological and chemical performance to downstream products. Key industries rely on this active core for high-value applications:
- Pharmaceutical Intermediates: Forms the active core of analgesics, anti-inflammatory agents, and targeted enzyme inhibitors.
- Agrochemical Intermediates: Acts as a key precursor for high-efficiency insecticides, fungicides, and selective herbicides.
- Specialty Chemicals: Operates as a ligand framework for metal complexes, dyes, and specialized catalysts.
A Versatile Building Block for Organic Synthesis
When using pyrazole for synthesis, process chemists benefit from predictable reactivity across both nitrogen and carbon positions on the ring. This predictable behavior allows for precise regioselective reactions, including alkylation, halogenation, and acylation. We provide high purity pyrazole to guarantee clean reaction routes, minimize side reactions, and optimize yield during multi-step organic synthesis.
Key Applications
As a versatile heterocyclic building block, our pyrazole chemical plays a critical role across fine chemicals, life sciences, and advanced material manufacturing. We supply high purity pyrazole engineered to meet strict quality thresholds, ensuring predictable performance in demanding synthesis routes.
Pyrazole in Pharmaceutical Intermediates
We supply pyrazole in pharmaceutical intermediates manufacturing where core purity determines final yield and quality.
API Core Scaffold: Serves as a vital structural ring in anti-inflammatory drugs, analgesics, and targeted therapeutic compounds.
Reliable Reaction Yields: Minimal background impurities prevent side reactions in complex multi-step organic synthesis.
Custom Synthesis Support: Our high-purity pyrazole for synthesis helps research teams streamline process development from pilot testing to full-scale drug manufacturing.
Pyrazole Agrochemical Intermediate
Modern crop protection depends heavily on nitrogen-rich heterocyclic rings.
Crop Protection Products: Widely used as a pyrazole agrochemical intermediate for modern fungicides, herbicides, and insecticides.
Enhanced Stability: Incorporating the 1H-pyrazole nucleus improves metabolic stability and targeted biological activity in field formulations.
Scalable Production: We provide steady bulk supply to keep agrochemical manufacturing lines running efficiently.
Heterocyclic Synthesis and Specialty Fine Chemicals
- Ring Construction: Acts as a key starting material for building complex fused rings and functionalized derivatives.
- Specialty Materials: Used in the production of optical brighteners, dyes, chelating agents, and specialized industrial catalysts.
- Custom Derivatives: Serves as the foundation for generating halogenated, alkylated, and aryl-substituted heterocyclic intermediates.
R&D Use and Route Development
- Bench-Scale Testing: Ideal for medicinal chemistry labs exploring novel pharmacological targets.
- Synthetic Route Optimization: Our consistent quality helps chemists standardize reaction conditions and optimize industrial scaling processes.
- Flexible Sourcing: Available in various package sizes to support both initial lab screening and bulk commercial scale-up.
Chemical and Physical Properties of Pyrazole
Molecular structure overview of 1H-pyrazole
Pyrazole (CAS 288-13-1) is a five-membered aromatic heterocycle containing two adjacent nitrogen atoms. Its planar ring system delivers strong aromatic stability, making this high purity pyrazole intermediate an ideal core building block for complex organic synthesis.
| Property | Specification Value |
|---|---|
| Molecular Formula | C3H4N2 |
| Molecular Weight | 68.08 g/mol |
| Ring Type | 1,2-Diazole / 1H-pyrazole |
Tautomeric behavior
Unsubstituted pyrazole exhibits prototropic tautomerism. The rapid migration of the NH proton between the two nitrogen atoms renders the 3 and 5 positions chemically equivalent. This dynamic equilibrium simplifies synthetic planning when designing downstream derivatives for pharma and agrochemical products.
Basicity and reactivity
As an amphoteric heterocycle, pyrazole chemical reactivity combines features of both pyridine and imidazole:
Amphoteric Character: Acts as a weak base (pKa ~2.5) and a weak acid (pKa ~14.2).
Electrophilic Substitution: Electrophilic attack occurs preferentially at the C-4 position (e.g., nitration, halogenation, sulfonation).
N-Functionalization: Deprotonation at N-1 creates a nucleophilic anion that smoothly undergoes alkylation, acylation, and coupling steps.
Thermal properties
Our technical pyrazole specification ensures predictable behavior during scale-up and thermal processing:
Melting Point: 67°C – 70°C
Boiling Point: 186°C – 188°C
Thermal Stability: Remains thermally intact at standard operating temperatures, reducing unwanted byproduct formation during industrial reactions.
Solubility behavior
This pyrazole for synthesis dissolves readily across polar and semi-polar solvent systems to optimize reaction kinetics and downstream workups:
Water: Highly soluble in water.
Organic Solvents: Freely soluble in ethanol, diethyl ether, chloroform, and benzene.
Process Efficiency: Rapid dissolution streamlines solvent selection and crystallization steps.
Stability notes
Our high purity pyrazole bulk supply maintains long-term quality when standard warehouse guidelines are met:
Environmental Resistance: Stable under normal ambient temperature and pressure.
Incompatibilities: Keep away from strong oxidizing agents and strong mineral acids to prevent unintended exothermic reactions.
Handling characteristics
We optimize our pyrazole chemical supply for easy plant handling and charging:
Physical Form: White to pale yellow crystalline solid or flakes at room temperature.
Moisture Sensitivity: Slightly hygroscopic; requires sealed packaging to prevent moisture absorption and caking.
Dust Management: Formulated for minimal dust generation during bulk handling and reactor loading.
Pyrazole Industrial Synthesis and Production Routes
We manufacture high purity pyrazole using optimized, scalable production pathways designed for commercial reliability and standard-setting purity.
Cyclocondensation Reaction Pathways
The primary industrial method to produce the pyrazole chemical involves cyclocondensation between hydrazine derivatives and three-carbon units:
- 1,3-Dicarbonyl Condensation: Reacting hydrazine hydrate with 1,3-dicarbonyl compounds efficiently yields the 1H-pyrazole heterocyclic core with high selectivity.
- Unsaturated Aldehyde Route: Reacting hydrazine with acrolein or propargyl derivatives offers an efficient, high-yield alternative for large-scale pyrazole bulk supply.
Raw Material Sourcing and Process Control
We manage critical reaction parameters from start to finish to guarantee high output and minimize impurities:
- High-Grade Feedstocks: Strict quality screening for incoming hydrazine hydrate and dicarbonyl raw materials.
- Thermal Control: Precise temperature regulation during cyclocondensation to suppress unwanted side reactions.
- In-Process Testing: Continuous GC tracking to ensure complete raw material conversion prior to isolation.
Purification and Batch Consistency
To deliver dependable pyrazole for synthesis, our facility focuses on rigorous post-reaction refining:
| Production Phase | Key Operation | Quality Impact |
|---|---|---|
| Crude Isolation | Solvent extraction & phase separation | Removes primary reaction byproducts |
| Refining | Vacuum distillation / Recrystallization | Yields high purity pyrazole intermediate |
| Batch Verification | GC and assay testing | Ensures tight batch-to-batch consistency |
Our standardized manufacturing setup guarantees that every shipment meets strict global procurement specifications for stability, purity, and performance.
High Purity Pyrazole Quality Assurance
We verify every single batch of our pyrazole chemical before it leaves our facility. Our multi-stage quality control process ensures that every batch meets rigid specifications, giving you dependable consistency for sensitive organic synthesis.
Rigorous Testing Methods and Impurity Control
To satisfy strict regulatory and technical demands, we monitor the chemical profile of our pyrazole CAS 288-13-1 using industry-standard analytical instruments:
- Purity Assay (GC/HPLC): Ensures high purity pyrazole levels (typically $ge$99.0%) with minimal organic impurities.
- Moisture Content (Karl Fischer): Keeps water levels within strict limits to prevent side reactions in downstream processes.
- Residual Solvent & Ash Analysis: Guarantees clean performance in pharmaceutical and agrochemical synthesis.
| Test Parameter | Specification Standard | Test Method |
|---|---|---|
| Appearance | White to off-white crystalline solid | Visual inspection |
| Assay (Purity) | $ge$ 99.0% | GC / HPLC |
| Melting Point | 67°C – 70°C | Capillary method |
| Moisture Content | $le$ 0.5% | Karl Fischer |
Essential Documentation with Every Shipment
Transparency is central to our supply process. We issue a full analytical documentation package for every order:
- Certificate of Analysis (pyrazole COA): Batch-specific test results matching your exact purchase order.
- Safety Data Sheet (pyrazole SDS): Updated GHS-compliant health, safety, and handling guidelines.
- Technical Data Sheet (TDS): Complete pyrazole specification details and physical property metrics.
Third-Party Inspection Support
For large pyrazole bulk supply orders or custom procurement protocols, we support independent third-party testing. We routinely work with internationally recognized inspection agencies such as SGS, Intertek, or BV to sample and verify product quality prior to global dispatch.
Safety and Handling
GHS hazard overview
Working with pyrazole chemical intermediates requires strict adherence to standard industrial safety protocols.
Signal Word: Danger
Hazard Classifications: Acute Toxicity (Oral, Category 4), Skin Corrosion/Irritation (Category 1B/2), Serious Eye Damage (Category 1), Reproductive Toxicity (Category 2).
Hazard Statements: Harmful if swallowed. Causes severe skin burns and eye damage. Suspected of damaging fertility or the unborn child.
Safe handling guidance
We recommend handling 1H-pyrazole under tight industrial safety controls:
Use exclusively in well-ventilated areas or under localized exhaust hoods.
Avoid any direct contact with skin, eyes, and clothing.
Do not inhale dust, fumes, or vapors during batch processing.
Wash thoroughly with soap and water after handling.
Personal protective equipment
Equip facility operators with appropriate PPE during handling and sampling:
Eye/Face: Chemical splash goggles or a full-face safety shield.
Hand & Body: Nitrile or butyl rubber chemical-resistant gloves and protective work suits.
Respiratory: NIOSH-approved dust/particle respirator (P95/N95) or full-face air-purifying respirator when dust is present.
Storage conditions
Maintain product purity and workplace safety with structured storage protocols:
Keep in cool, dry, and well-ventilated areas away from direct heat sources and sunlight.
Store containers tightly sealed in an upright position when not in use.
Recommended storage temperature: 15°C to 25°C (59°F to 77°F).
Incompatibilities
Keep pyrazole CAS 288-13-1 isolated from reactive compounds:
Incompatible Substances: Strong oxidizing agents, strong acids, acid chlorides, and acid anhydrides.
Decomposition Products: Thermal breakdown releases toxic fumes, including nitrogen oxides (NOx), carbon monoxide, and carbon dioxide.
First-aid and spill response note
Follow these quick protocols in case of exposure or accidental discharge:
Eye Contact: Immediately flush eyes with running water for at least 15 minutes. Seek prompt medical care.
Skin Contact: Remove contaminated clothing and wash skin thoroughly with plenty of water and soap.
Inhalation: Move the affected individual to fresh air immediately. Provide oxygen or artificial respiration if required.
Spill Clean-up: Evacuate non-essential staff. Wear full PPE, carefully sweep up the solid material without generating dust, and place it into sealed containers for proper hazardous waste disposal.
Transportation and labeling considerations
We ensure complete global compliance for every pyrazole bulk supply order:
UN Number: UN 3263 (Corrosive solid, basic, organic, n.o.s.) or relevant transport classification based on exact product grade.
Hazard Class: Class 8 (Corrosive).
Packing Group: PG II / PG III.
Documentation & Markings: All outer packaging includes GHS-compliant warning labels, proper shipping names, and a full pyrazole SDS to guarantee hassle-free international transit and customs clearance.
Packaging and Supply Options
We offer flexible, export-ready pyrazole bulk supply and packaging options tailored to your exact scale and logistics requirements. From bench-scale testing to full commercial production, we protect product integrity through every step of shipping.
Industrial Packaging Specifications
| Packaging Type | Capacity | Ideal Application |
|---|---|---|
| R&D Samples | 100 g – 1 kg | Sealed foil pouches / HDPE bottles for lab testing |
| Standard Drums | 25 kg / drum | Fiber drums with double PE inner liners |
| Bulk Bags / Large Drums | 500 kg+ | Heavy-duty UN-approved packaging for industrial volumes |
| Custom Packaging | Made to order | Tailored containers matched to your handling systems |
Global Logistics and Documentation Support
- Sample Dispatch: Fast-track delivery of sample batches so you can verify purity and specs before placing bulk orders.
- Custom Solutions: Specialized palletization, shrink-wrapping, nitrogen flushing, and moisture barrier protection available upon request.
- Export Compliance: Complete UN-certified packaging designed to meet international maritime (IMDG) and air (IATA) shipping regulations.
- Private Labeling & Custom Docs: Customized labeling, custom HS codes, COA, SDS, and tailored packing lists aligned with your local customs requirements.
As a direct pyrazole supplier, we ensure every shipment arrives safely, securely, and fully documented for immediate seamless integration into your process.
Reliable Pyrazole Supplier for Global Bulk Supply
We provide direct factory access to high purity pyrazole with a secure supply chain built for seamless commercial procurement. As a direct pyrazole manufacturer, we simplify your sourcing process with flexible purchasing terms, predictable lead times, and total export compliance.
Factory-Direct Supply Chain
- Direct Sourcing: Eliminate intermediary markups and secure direct access to our manufacturing stream.
- Stable Volume: Continuous production capacity keeps your synthesis lines running without unexpected supply disruptions.
- Traceable Batches: Complete transparency from raw material sourcing to final delivery.
Flexible MOQ and Order Capacity
| Commercial Parameter | Capability & Guidance |
|---|---|
| Minimum Order Quantity (MOQ) | Flexible tiers tailored for pilot-scale trials up to multi-ton commercial contracts |
| Standard Lead Time | 3 to 7 business days for stock dispatch; scheduled delivery plans for recurring contracts |
| Global Shipping | Full air, sea, and multimodal logistics support with complete hazardous/non-hazardous export documentation |
RFQ Pricing Model
We use a real-time RFQ (Request for Quotation) pricing system. This ensures you receive the most accurate pyrazole price based on current raw material dynamics, order volume, packaging choices, and target port logistics. Contact us directly with your target specifications to receive a customized quote.
Why Choose Greenlano as Your Pyrazole Supplier
At Greenlano, we streamline your chemical sourcing by delivering high-purity pyrazole directly from our production facilities. As an established pyrazole manufacturer, we combine competitive factory pricing with total supply chain transparency, ensuring your production stays on schedule and within budget.
| Service Feature | Procurement Benefit |
|---|---|
| Factory-Direct Sourcing | Eliminates middleman markups for optimal bulk pricing. |
| Batch Traceability | End-to-end lot tracking with verified batch COAs. |
| Strict Quality Control | Rigorous testing ensures high purity across every shipment. |
| Fast Quotation Response | Quick turnarounds on RFQs to keep your sourcing moving. |
| Export Compliance | Full regulatory and SDS documentation for global customs clearance. |
Reliable B2B Service and Global Logistics
We build our operations around the real-world demands of chemical procurement managers and research teams:
- Uncompromised Quality Control: Every shipment of pyrazole CAS 288-13-1 is tested for purity, appearance, and assay consistency before leaving our warehouse.
- Traceable Production: We retain raw material records and batch samples to guarantee full batch traceability from raw material to delivery.
- Dedicated Commercial Support: Our team delivers prompt price quotes, sample dispatch, and transparent lead time updates tailored to your project deadlines.
- Seamless Export Shipping: From customized drum packaging to compliant hazard labeling, we manage the technical and logistics details for secure pyrazole bulk supply anywhere in the world.
Related Products and Pyrazole Derivatives
We supply a comprehensive range of pyrazole derivatives tailored to meet your exact synthesis requirements. Whether you are scaling up active pharmaceutical ingredients (APIs) or formulating advanced crop protection products, our portfolio delivers consistent quality across every batch.
Substituted Pyrazoles
Functionalized pyrazole intermediates provide versatile synthetic handles for complex heterocyclic ring construction:
- Methyl Pyrazoles: High-purity 3-methylpyrazole and 4-methylpyrazole used widely as targeted building blocks and specialized inhibitors.
- Halogenated Pyrazoles: Chlorinated and brominated pyrazole intermediates engineered for precise cross-coupling and nucleophilic substitution reactions.
- Functional Intermediates: Custom-substituted analogs designed specifically for multi-step pharmaceutical intermediates and agrochemical intermediate synthesis.
Flexible Sourcing for R&D and Production
As an established pyrazole supplier, we offer seamless volume scaling from small-scale R&D samples to full commercial production. Every pyrazole chemical derivative in our catalog is backed by strict quality control and full analytical documentation to streamline your supply chain.
Frequently Asked Questions About Pyrazole
What is the CAS number of pyrazole?
The CAS number for high purity 1H-pyrazole is 288-13-1.
What is pyrazole used for?
As a versatile chemical intermediate, pyrazole is widely used in:
Pharmaceutical synthesis: Key building block for active pharmaceutical ingredients (APIs).
Agrochemical intermediates: Core raw material for fungicides, herbicides, and insecticides.
Specialty chemicals: Fundamental heterocyclic compound for custom synthesis and organic R&D.
Is pyrazole suitable for pharmaceutical synthesis?
Yes. We supply high purity pyrazole manufactured under strict quality control standards, ensuring low impurity profiles ideal for active pharmaceutical intermediate manufacturing and drug discovery.
What documents can Greenlano provide?
We provide full technical and regulatory documentation for every shipment, including:
Certificate of Analysis (COA) (batch-specific)
Safety Data Sheet (SDS / MSDS)
Technical Data Sheet (TDS)
What is the minimum order quantity?
We accommodate both development and commercial demands. Our flexible MOQ supports small R&D testing orders as well as multi-ton bulk supply. Contact us to discuss your specific volume requirements.
Can I request a sample before bulk purchase?
Yes. We provide sample packages for testing and analytical verification so you can confirm our quality standards prior to placing a full commercial order.
How is pyrazole packaged and shipped?
Our standard packaging includes air-tight fiber drums and moisture-proof industrial bags. We also offer custom packaging tailored to your process needs and handle full export shipping compliance for secure global transit.
What safety documents are available?
We supply GHS-compliant pyrazole SDS documents detailing complete safety guidelines, hazard classifications, protective equipment (PPE) recommendations, safe handling protocols, and spill response procedures.