Formula details
Product Details
Overview
O-Vanillin Product Overview
We manufacture and supply high-purity O-Vanillin (≥ 99.0% purity grade by HPLC/GC) to support advanced pharmaceutical research, fine chemical production, and specialized ligand synthesis. Positioned as a key organic synthesis intermediate and functional building block, our direct manufacturing infrastructure ensures reliable batch-to-batch consistency, competitive pricing, and full global export compliance.
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- Product Name: O-Vanillin (3-Methoxysalicylaldehyde)
- CAS Number: 148-53-8
- Purity Assay: ≥ 99.0%
- Chemical Role: Functional aldehyde building block & organic synthesis intermediate
- Supply Capabilities: Direct factory sourcing, certified quality control, global export support
ortho-Vanillin vs. para-Vanillin
Choosing between O-Vanillin (2-hydroxy-3-methoxybenzaldehyde) and conventional Para-Vanillin (4-hydroxy-3-methoxybenzaldehyde) comes down to structural regiochemistry. The substitution pattern directly dictates reactivity, thermal behavior, and coordination strength.
The adjacent hydroxyl (-OH) and formyl (-CHO) groups in O-Vanillin form strong intramolecular hydrogen bonds, creating a distinct physical and chemical profile compared to its para-counterpart.
| Structural Feature | O-Vanillin (ortho-Vanillin) | Para-Vanillin (para-Vanillin) |
|---|---|---|
| IUPAC Name | 2-Hydroxy-3-methoxybenzaldehyde | 4-Hydroxy-3-methoxybenzaldehyde |
| CAS Number | 148-53-8 | 121-33-5 |
| Hydrogen Bonding | Strong intramolecular chelation ring | Intermolecular hydrogen network |
| Melting Point | 40°C – 42°C (reduced lattice energy) | 81°C – 83°C |
| Redox & Reactivity | Shifted oxidation potential; specialized electron density | Standard phenolic reaction pathways |
| Chelation Ability | Superior bidentate/multidentate coordination site | Weak coordination site |
Structural & Performance Benefits
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- Modified Physical Constants: Intramolecular bonding lowers the melting point and enhances volatility and solubility in non-polar organic solvents.
- Redox Control: The proximity of functional groups stabilizes specific transition states and modifies redox behavior during catalytic cycles.
- Enhanced Coordination Chemistry: The adjacent oxygen atoms form an optimal chelating pocket, making O-Vanillin a premier Schiff base ligand precursor for metal complexes, lanthanide chemistry, and catalytic frameworks.
Technical Specifications & Physical Parameters
We manufacture high-purity O-Vanillin (2-Hydroxy-3-methoxybenzaldehyde) under strict quality standards. Below are the core physical and chemical specifications for our commercial supply.
CAS 148-53-8 Technical Data
| Parameter | Specification Constants |
|---|---|
| Product Name | O-Vanillin (ortho-Vanillin) |
| IUPAC Name | 2-Hydroxy-3-methoxybenzaldehyde |
| CAS Number | 148-53-8 |
| EC Number | 205-715-3 |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 g/mol |
| Purity (HPLC/GC) | >= 99.0% |
| Appearance | Light yellow crystalline solid |
| Melting Point | 40°C – 42°C |
| Boiling Point | 265°C – 266°C |
| Solubility | Soluble in ethanol, methanol, ether, and chloroform; sparingly soluble in water |
Analytical & Quality Control Protocols
To guarantee batch-to-batch consistency, every lot of our ortho-Vanillin HPLC 99% undergoes standard in-house release testing before packaging:
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- HPLC & GC Assay: We confirm chemical purity and monitor trace impurities using validated High-Performance Liquid Chromatography and Gas Chromatography methods.
- Proton NMR Verification: Spectral identity testing confirms the precise C8H8O3 molecular structure and rules out structural isomers.
- Karl Fischer Titration: Precise water content determination ensures low moisture levels across all commercial batches.
- Loss on Drying (LOD): Standardized thermal testing verifies minimal residual solvent levels and volatile organic content.
Key Applications & Reaction Utility
We supply high-purity O-Vanillin (2-Hydroxy-3-methoxybenzaldehyde) as a versatile reaction building block across pharmaceuticals, coordination chemistry, and specialty chemical manufacturing. Its dual reactive functional groups allow precise synthetic transformations with predictable batch performance.
Pharmaceutical Intermediate & API Synthesis
Our O-Vanillin synthesis intermediate plays a critical role in constructing targeted drug candidates and medicinal chemistry scaffolds:
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- Cardiovascular & Respiratory Actives: Functions as a direct precursor in the multi-step synthesis of active agents, including benafentrine and pentomone.
- Heterocyclic Scaffold Construction: Serves as a primary reactant for assembling modified benzofurans, chromenes, and nitrogen-containing heterocycles in API research.
Schiff Base Ligand Synthesis & Coordination Chemistry
Because the hydroxyl and aldehyde groups sit adjacent to each other on the benzene ring, O-Vanillin acts as a top-tier Schiff base ligand precursor:
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- Primary Amine Condensation: Easily reacts with mono- and polyamines to generate multidentate ligands tailored for transition-metal catalytic complexes.
- Advanced Functional Materials: Core building block for engineering single-molecule magnets (SMMs), molecular sensors, and luminescent lanthanide complexes used in advanced materials research.
Specialty Organic Synthesis & Agrochemical Compounding
We support chemical producers who rely on this organic synthesis aldehyde building block for high-value fine chemical formulations:
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- Coumarins & Biological Probes: Serves as an essential precursor for coumarin derivatives, fluorescent biological probes, and specialized dyes.
- Crop Protection & Antioxidants: Acts as a active backbone for target-specific antifungal, antimicrobial, and antioxidant formulations in modern agrochemical research.
Quality Control & Regulatory Compliance
Strict Quality Assurance Standards
We enforce strict batch-level verification for every shipment of O-Vanillin (CAS 148-53-8). Every lot undergoes rigorous in-house pre-shipment laboratory testing to guarantee high-purity ortho-Vanillin HPLC >= 99.0% standards before dispatch.
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- 100% Pre-Shipment Testing: Complete HPLC assay, GC profile, Karl Fischer moisture check, and NMR structural verification for every lot.
- Third-Party Inspection: Full support for independent pre-shipment quality audits by SGS or Bureau Veritas upon customer request.
- Batch-to-Batch Consistency: Tight specification limits prevent lot variance and eliminate supply chain delays in downstream organic synthesis.
Complete Regulatory Documentation Package
We streamline your chemical regulatory audits by delivering a full compliance package with every shipment of O-Vanillin.
| Document | Content & Technical Scope | Standards & Compliance |
|---|---|---|
| O-Vanillin COA Certificate of Analysis | Batch-specific analytical values (purity %, melting point, loss on drying) | ISO 9001 Certified |
| O-Vanillin MSDS SDS Download | Full hazard identification, emergency response, and safe storage protocols | GHS Compliant |
| Technical Data Sheet (TDS) | Physical parameters, solubility specs, and chemical constants | Factory Standard |
| REACH Regulatory Support | Direct documentation assistance for market entry across the EU | EU REACH Compliant |
O-Vanillin Packaging, Storage & Safe Handling
We supply high-purity O-Vanillin (CAS 148-53-8) in secure, industrial-grade packaging designed to maintain product purity and prevent moisture contamination during international transit.
Commercial Packaging Options
We offer flexible packaging configurations tailored to your specific order volume and manufacturing requirements:
| Packaging Type | Standard Net Weight | Inner Container | Outer Packaging |
|---|---|---|---|
| R&D / Sample Pack | 1 kg | Vacuum-sealed aluminum foil bag | Cardboard box |
| Standard Commercial Drum | 25 kg | Double PE inner liner bags | Heavy-duty fiber drum |
| Bulk Custom Freight | Metric-ton volumes | Double-lined drum arrays | Palletized, shrink-wrapped units |
Storage & Handling Recommendations
To preserve chemical stability and avoid melting or discoloration, follow these storage practices for O-Vanillin:
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- Environment: Keep containers tightly closed in a cool, dry, dark, and well-ventilated facility.
- Temperature: Store below 30°C away from direct sunlight, radiant heat, and ignition sources.
- Incompatibilities: Keep separated from strong oxidizing agents and strong bases.
Safety & Hazard Classification
Our O-Vanillin product labeling complies fully with standard GHS regulatory requirements.
| Safety Parameter | Hazard & Handling Profile |
|---|---|
| GHS Pictogram | GHS07 (Warning) |
| Hazard Statements | H302: Harmful if swallowed H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation |
| Handling Precautions | Use under local exhaust ventilation or a chemical fume hood. Wear safety goggles, nitrile gloves, and a dust mask/respirator. |
Commercial Sourcing & Direct RFQ for O-Vanillin
Why Source O-Vanillin Directly
We supply high-purity O-Vanillin (≥ 99.0% HPLC) directly from our chemical manufacturing facilities to global industrial buyers, eliminating trading markups and streamlining your supply chain.
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- Direct Factory Pricing: Maximize cost efficiency with transparent pricing on bulk synthesis intermediates.
- 24-Hour Documentation Turnaround: Instant access to tech specs, regulatory documents, and batch-specific O-Vanillin COA certificate of analysis copies.
- Global Freight Compliance: Complete compliance with international hazardous materials (HazMat) shipping, dangerous goods packaging, and export regulations.
Request a Bulk Quote and COA
Submit your requirements directly to our commercial team to receive an instant O-Vanillin price per kg, custom freight estimates, and batch testing data.
| Inquiry Detail | Information to Provide |
|---|---|
| Target Purity | Standard Grade (≥ 99.0%) or specific analytical parameters |
| Order Volume | Evaluation samples, Kilograms (kg), or Metric Ton shipments |
| Shipping Destination | Destination port, country, and delivery timeline requirements |
| Documentation Package | Batch COA, O-Vanillin MSDS SDS download, or TDS files |
| Business Contact | Corporate email, company details, and phone number |
Frequently Asked Questions About O-Vanillin
What is O-Vanillin and how does it differ from standard vanillin?
O-Vanillin (2-Hydroxy-3-methoxybenzaldehyde, CAS 148-53-8) is a structural isomer of standard para-vanillin. The main difference in ortho-vanillin vs para-vanillin lies in the functional group placement on the benzene ring:
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- O-Vanillin: The hydroxyl (-OH) group is at the C-2 position, directly adjacent to the aldehyde (-CHO) group.
- Para-Vanillin: The hydroxyl (-OH) group is at the C-4 position.
This adjacent position creates strong intramolecular hydrogen bonding in O-Vanillin. As a result, it exhibits a lower melting point (40°C–42°C), altered redox behavior, distinct organic solubility, and exceptional metal-complexation capabilities.
Purity Grades and Quality Testing Protocols
We manufacture and supply high-purity ortho-vanillin HPLC 99% minimum grade to meet strict industrial and lab requirements. Every lot undergoes rigorous testing prior to dispatch:
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- Purity Assay: Verified via High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) to guarantee >= 99.0% purity.
- Structural Identity: Proton NMR spectral verification for absolute chemical identification.
- Moisture Control: Karl Fischer titration and Loss on Drying (LOD) parameters to ensure low moisture levels.
Key Applications in Organic Synthesis and Schiff Base Chemistry
As a versatile organic synthesis aldehyde building block, O-Vanillin is widely used across several high-value chemical sectors:
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- Schiff Base Ligand Precursor: Reacts smoothly with primary amines to form multidentate chelating ligands for metal-complex catalysts, single-molecule magnets (SMMs), and luminescent lanthanide complexes.
- Pharmaceutical Synthesis: Functions as a core intermediate in synthesizing cardiovascular and respiratory active agents (such as benafentrine and pentomone) and heterocyclic scaffolds.
- Specialty Chemicals: Serves as a key starting material for coumarins, fluorescent probes, and target-specific antifungal and antimicrobial formulations.
Storage and Safe Handling Recommendations
To prevent chemical degradation or color shifting over time, follow these storage guidelines for bulk O-Vanillin:
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- Temperature & Environment: Keep sealed in a cool, dry, dark, and well-ventilated area at temperatures below 30°C.
- Chemical Incompatibilities: Store away from strong oxidizing agents, strong bases, and direct heat sources.
- Packaging Protection: Keep product inside original sealed packages, such as 1 kg aluminum bags or 25 kg fiber drums with double PE inner liners, until ready for production.
How to Get an O-Vanillin COA, MSDS, or Direct Factory Quote
We offer direct factory pricing, eliminating middleman markups to support both pilot-scale and commercial bulk demands.
To request an O-Vanillin COA certificate of analysis, O-Vanillin MSDS SDS download, or an updated O-Vanillin price per kg, simply reach out to our team with:
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- Your required order volume (kg or metric tons)
- Target purity specifications
- Destination port or delivery location
We process all inquiries rapidly, delivering complete technical documentation and official quotes within 24 hours.